WebMay 5, 2016 · Tumor evolution and cell phylogeny. a Schematic representation of tumor evolution with time progressing downwards. Stars denote new mutations leading to subclone expansion. The quadrangles belong to minor extinct subclones with no traces in the present-day populations. WebMay 4, 2024 · Previously, we introduced the self-assembling manifold (SAM) algorithm to robustly reconstruct manifolds from single-cell data (Tarashansky et al., 2024). Here, we build on SAM to map cell atlas ...
Evolutionary cell type mapping with single-cell genomics
WebOct 1, 2024 · Cell types are the basic functional units of multicellular organisms. So far, cell taxonomies remain Linnaean. Single-cell transcriptomic methods enable the systematic characterization of cell diversity in understudied animal lineages. These data-driven cell catalogs should allow us to organize cell diversity into evolutionary classification ... WebMapping the cell phylogeny of a complex multicellular organism relies on somatic mutations accumulated from zygote to adult. Available cell barcoding methods can … luther woodall obituary alabama
Chang Ye - Google Scholar
WebMar 29, 2024 · Reconstructing the history of somatic DNA alterations can help understand the evolution of a tumor and predict its resistance to treatment. Single-cell DNA sequencing (scDNAseq) can be used to investigate clonal heterogeneity and to inform phylogeny reconstruction. However, most existing phylogenetic methods for scDNAseq data are … WebJan 23, 2024 · Our approach not only provides a framework for enabling variant-to-function insights at single-cell resolution, but also suggests a more general strategy for … WebPhylogenetically Mapping Single Mouse Cells. We then attempted to construct a cell fate map of a mouse by examining tissues obtained from a single adult specimen. An initial consideration is that only mutations that have arisen early enough in development to have been inherited by a majority of the cells in the sampled tissue can be detected. luther wood palm desert