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Fhl2 transcription factor

WebMar 21, 2024 · FHL2 (Four And A Half LIM Domains 2) is a Protein Coding gene. Diseases associated with FHL2 include Familial Isolated Dilated Cardiomyopathy and Rhabdomyosarcoma . Among its related pathways … WebJul 8, 2024 · Several forensic studies consistently found FHL2 to be one of the DNA methylation markers that correlate most significantly with ageing [ 6, 7, 8, 9 ]. FHL2 is …

Frontiers FHL2 Regulates Natural Killer Cell Development and ...

WebNov 1, 2015 · The FHL2 regulation in the transcriptional circuitry of human cancers. The Four-and-a-half LIM (FHL)-only protein is a subfamily of protein members under the LIM … WebThe LIM-only protein FHL2 is a scaffolding protein that modulates signal transduction pathways with crucial functions in endothelial and smooth muscle cells. However, the role of FHL2 in TF regulation and thrombosis remains unexplored. phillip \u0026 sala burton academic high school https://asouma.com

Biology and clinical relevance of EpCAM - PMC

Web15206 Ensembl ENSG00000069812 ENSMUSG00000028940 UniProt Q9Y543 O54792 RefSeq (mRNA) NM_019089 NM_001301805 NM_008236 RefSeq (protein) NP_061962 … WebAug 30, 2024 · Purpose: Increasing evidence demonstrates that the four and a half LIM domain (FHL) gene and its protein products have different functions in the progression of various malignancies. However, the role of FHL protein 2 (FHL2) in cervical cancer (CC) has not been fully elucidated. In this study, we investigated the prognostic value of FHL2 … WebApr 11, 2013 · FHL2 functions as a coactivator with HCF-1 for stimulation of IE gene transcription. (Bottom Panel) The essential coactivator HCF-1 interacts directly with transcription factors and coactivators that mediate IE gene expression (yellow arrows). ts705a canon

FHL2 expression and variants in hypertrophic cardiomyopathy

Category:FHL2 deficiency impairs follicular development and …

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Fhl2 transcription factor

Fhl2 deficiency results in osteopenia due to decreased ... - PubMed

WebJan 18, 2013 · FHL2 cooperates with Arkadia in activation of Smad3/Smad4-dependent transcription. A, 293T cells were transfected with the TGF-β-responsive luciferase reporter (CAGA) 12-Luc (0.1 μg) together with Arkadia or C937A and increasing doses of FHL2 (0.1 μg and 0.3 μg). TK-Renilla was used as internal control. WebWe demonstrate that FHL2 interacts with beta-catenin, a key player involved in bone formation induced by Wnt signaling. FHL2-beta-catenin interaction potentiates beta-catenin nuclear translocation and TCF/LEF transcription, resulting in increased Runx2 and alkaline phosphatase expression, which was inhibited by the Wnt inhibitor DKK1.

Fhl2 transcription factor

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http://www.cancerindex.org/geneweb/FHL2.htm WebThe transcriptional co-factor FHL2 (four and a half LIM domains protein 2) acts as an oncoprotein or as a tumor suppressor depending on the tissue context. In this study, we …

Web5,351 transcription cofactor Silencer Select Pre-designed, Validated, and Custom siRNA in Standard, HPLC, and In-vivo Ready Purities. WebApr 28, 2024 · FHL2 has been described as a coactivator for several transcription factors like the androgen receptor, AP-1 or β-catenin 21,34,35. In these studies, reporter gene experiments demonstrated that ...

WebWe previously reported that FHL2 mediates TGF-β1-induced tubular epithelial-to-mesenchymal transition through activating Wnt/β-catenin signaling. However, the potential role and mechanism for FHL2 in TGF-β1-induced fibroblast activation and kidney fibrosis remains unknown. WebNoteworthy, this C-terminal filamin–FHL2–AR-V transcriptional complex exists in CRPC but not in benign prostate tissue or localized PCa. Importantly, this complex is also able to enhance the constitutive transcriptional activity of AR-V7 under castrate conditions. Vav3 is a Rho GTPase and a coactivator for full-length AR.

WebThe goal of this study is to clear the mechanism of antiangiogenic signaling of FHL-2 in endothelial cells (ECs). Methods and results: In the angiogenic signaling, we focused on sphingosine kinase-1 (SK1), which produces sphingosine-1-phosphate (S1P), a bioactive sphingolipid, as a potent angiogenic mediator in ECs. ts72-6mh-400 h2WebSep 21, 2004 · ACT is a LIM-only protein that interacts with transcription factor CREM (123812) in postmeiotic male germ cells and enhances CREM-dependent transcription (Kotaja et al., 2004). ... ACT shares 58.5% identity with FHL2 (602633) and 85% identity with mouse Act. Northern blot analysis revealed moderate to high levels of expression in … phillip\u0027s flowers chicagoWebJul 14, 2016 · The four and a half LIM domains 2 (FHL2) has been shown to play important roles in the regulation of cell proliferation, survival, adhesion, motility and signal … ts70 red geo series gaming chair