WebConor R. Caffrey Schistosomiasis is a parasitic disease that affects approximately 200 million people in developing countries. Current treatment relies on just one partially effective drug, and ... WebDec 11, 2024 · Approximately ten percent of the world’s population is at risk of schistosomiasis, a neglected, parasitic disease of poverty caused by the Schistosoma flatworm. To facilitate drug discovery for this complex organism, we developed an automated, time-lapsed high-content (HC) screen to quantify the multi-dimensional …
Schistosomiasis and its treatment - ResearchGate
WebDec 1, 2024 · Praziquantel (PZQ) is the only drug available for community-based control programs which aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we synthesized and evaluated the schistosomicidal, biochemical and cytotoxic activities of EF24, a synthetic curcumin analog, against different isolates of … WebSchistosomiasis is one of a number of ‘neglected tropical diseases’ (NTDs) associated with extreme poverty in the world’s ‘bottom billion’ people [1]. Caused by a parasitic flatworm, the disease can be fatal, but is better known for its chronicity of infection (e.g., [2]). Clinical manifestations of chronic infection high heel shoes in trinidad
Parasitic Helminths: Targets, Screens, Drugs and …
WebDrug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening Maha-Hamadien Abdulla1., Debbie S. Ruelas1., Brian Wolff2, June Snedecor2, Kee-Chong Lim1, Fengyun Xu1, Adam R. Renslo2, Janice Williams2, James H. McKerrow1, Conor R. Caffrey1* 1Sandler … WebSchistosomiasis is a helmintic disease of extreme poverty infecting over 200 million people and putting approximately 800 million people at risk across our planet. This debilitating … WebSchistosomiasis is a chronic and morbid disease that affects hundreds of millions of the poorest individuals in (sub)tropical regions, particularly sub-Saharan Africa. Just one … how intense its influence is